Question 1

Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations

Accepted Answer

Franck Mauvais-Jarvis and Sarah H Lindsey

Click here to read the publication:
Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations >> 
J Clin Invest. 2024 Sep 3;134(17):e180073. PMID: 39225098

Question 2

Sex differences in energy metabolism: natural selection, mechanisms and consequences

Accepted Answer

Franck Mauvais-Jarvis

Click here to read the publication:
Sex differences in energy metabolism: natural selection, mechanisms and consequences >> 
Nat Rev Nephrol. 20: 56–69. January 2024. PMID: 37923858

Question 3

Sex- and gender-based pharmacological response to drugs

Accepted Answer

Franck Mauvais-Jarvis, Heiner K. Berthold, Ilaria Campesi, Juan-Jesus  Carrero, Santosh Dakal, Flavia Franconi, Ioanna Gouni-Berthold, Mark L.  Heiman, Alexandra Kautzky-Willer, Sabra L. Klein, Anne Murphy, Vera  Regitz-Zagrosek, Karen Reue, and Joshua B. Rubin

Click here to read the publication:
Sex- and gender-based pharmacological response to drugs >> 
Pharmacol Rev. 73: 730–762. April 2021. PMID: 33653873

Question 4

Sex and gender: modifiers of health, disease, and medicine

Accepted Answer

Franck Mauvais-Jarvis, Noel Bairey Merz, Peter J Barnes, Roberta D  Brinton, Juan-Jesus Carrero, Dawn L DeMeo, Geert J De Vries, C Neill  Epperson, Ramaswamy Govindan, Sabra L Klein, Amedeo Lonardo, Pauline M  Maki, Louise D McCullough, Vera Regitz-Zagrosek, Judith G Regensteiner,  Joshua B Rubin, Kathryn Sandberg, and Ayako Suzuki

Click here to read the publication:
Sex and gender: modifiers of health, disease, and medicine >> 
Lancet. 396: 565–82.  September 2020. PMID: 32828189

Question 5

Analysis of sex differences in pre-clinical and clinical data sets

Accepted Answer

Adriene M. Beltz, Annaliese K. Beery, and Jill B. Becker

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Analysis of sex differences in pre-clinical and clinical data sets >>
Neuropsychopharmacology. 2019 Dec;44(13):2155-2158. PMID: 31527863

Question 6

A guide for the design of pre-clinical studies on sex differences in metabolism

Accepted Answer

Franck Mauvais-Jarvis, Arthur P. Arnold, and Karen Reue

Click here to read the publication:
A guide for the design of pre-clinical studies on sex differences in metabolism >> 
Cell Metabolism. 25: 1216-1230. June 2017. PMID: 28591630

Question 7

Sex differences in metabolic homeostasis, diabetes, and obesity

Accepted Answer

Franck Mauvais-Jarvis

Click here to read the publication:
Sex differences in metabolic homeostasis, diabetes, and obesity >> 
Biology of Sex Differences. 6:14. September 2015. PMID: 26339468

Question 8

Reporting and misreporting of sex differences in the biological sciences

Accepted Answer

Yesenia Garcia-Sifuentes, Donna L Maney

Click here to read the publication:
Reporting and misreporting of sex differences in the biological sciences >>
eLife. 2021 Nov 2. 10:e70817. PMID: 34726154

Question 9

Picking a research problem. The critical decision

Accepted Answer

C. Ronald Kahn

Picking a research problem. The critical decision

Click here to read the publication:
Picking a research problem. The critical decision >> 
N Engl J Med. 1994 May 26;330(21):1530-3. PMID: 8164709.

Essential Reading

Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations

Sex differences in energy metabolism: natural selection, mechanisms and consequences

Sex- and gender-based pharmacological response to drugs

Sex and gender: modifiers of health, disease, and medicine

Analysis of sex differences in pre-clinical and clinical data sets

A guide for the design of pre-clinical studies on sex differences in metabolism

Sex differences in metabolic homeostasis, diabetes, and obesity

Reporting and misreporting of sex differences in the biological sciences

Picking a research problem. The critical decision