Mark Mondrinos, PhD

Bioengineering Microphysiological Models of Sex-specific Pathophysiology​

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Dr. Mondrinos' research aims to develop microphysiological systems (MPS) to model sex-specific mechanisms in diseases affecting the outer retinal microvasculature. By combining 2D and 3D culture systems, his lab will assess how estrogen and androgen influence bioenergetic function, vasculogenic potential, and transcriptomic profiles using sex-matched and cross-sex hormone environments. These models will be used to study inflammatory disruption of endothelial barrier function and VEGF-driven sprouting angiogenesis - key processes in conditions like diabetic retinopathy. His research will provide insights into sex-specific and gender-affirming hormone effects on vascular pathology and identify biomarkers for sex- and gender-based therapeutic strategies.